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Revved-Up Protein Fights Aging
An unlikely, decadelong journey that began with the discovery of a rapidly aging mouse has led scientists to a protein that seems to protect animals from cancer and other scourges of old age—with no apparent downsides. There are still lots of mysteries about the protein, called BubR1, but the work offers clues about how protecting chromosomes can enhance health.

Cancer biologist Jan van Deursen at the Mayo Clinic in Rochester, Minnesota, and his colleagues were initially interested in studying a common feature of cancers, called aneuploidy. Aneuploid cells have too few or too many chromosomes. Nearly all cancer cells fall into this category, but it's not clear whether aneuploidy actually causes cancer. van Deursen, along with a then-graduate student, Darren Baker, engineered mice to produce less BubR1, a protein that helps cells segregate their chromosomes when they divide. When BubR1 is reduced, chromosomes can't properly separate into identical daughter cells, leaving some daughters with the wrong number of chromosomes. van Deursen, Baker, and their colleagues wanted to see whether these mice would develop cancer.
read more: http://news.sciencemag.org/sciencenow/2012/12/revved-up-protein-fights-aging.html click here

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